Hydrazine hydrate (1:1) → HCID 66878617, Verbindung

HRID 1878371Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1878371
[N:1]1[CH:6]=[C:5]([C:7]([O:9][CH2:10][CH3:11])=[O:8])[N:4]=[CH:3][C:2]=1[C:12]([O:14]CC)=O.O.[NH2:18][NH2:19]>C(O)C>[NH:18]([C:12]([C:2]1[N:1]=[CH:6][C:5]([C:7]([O:9][CH2:10][CH3:11])=[O:8])=[N:4][CH:3]=1)=[O:14])[NH2:19]

Komponenten

4

Edukt 2

HCID 24654Hydrazine hydrate (1:1)HCID 13692208Diethyl pyrazine-2,5-dicarboxylate

Produkt 1

HCID 66878617HCID 66878617, VerbindungAusbeute 71,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel2×

Reaktionsbedingungen

Temperatur
75 °C

Versuchsvorschrift

A mixture of diethyl pyrazine-2,5-dicarboxylate (1.75 g, 7.81 mmol) and ethanol (15 mL) was heated to 75° C. to obtain a homogeneous solution. After cooling to room temperature, a solution of hydrazine monohydrate (0.281 g, 7.03 mmol) in ethanol (3.5 mL) was added to the solution dropwise over 4 hours. After stirring at room temperature overnight, a solid had precipitated out of the reaction mixture. The solid was collected by filtration and dried under vacuum to give the title compound (1.05 g).

Aufarbeitung

  1. customto obtain a homogeneous solution
  2. temperatureAfter cooling to room temperature
  3. customa solid had precipitated out of the reaction mixture
  4. filtrationThe solid was collected by filtration
  5. customdried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-941fc9a125a447aebfc20a695f23ac30
Quelldatensatz
uspto-grants-2012_11
Patentnummer
US08314091B2

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