Sodium Carbonate → HCID 57448056, Verbindung

HRID 1879062Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1879062
[F:1][C:2]([F:19])([F:18])[C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([CH:11]2[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]2)[C:6]=1[F:17])=[O:4].[BH4-].[Na+].C(=O)([O-])[O-].[Na+].[Na+]>C(O)C>[F:19][C:2]([F:1])([F:18])[CH:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([CH:11]2[CH2:12][CH2:13][NH:14][CH2:15][CH2:16]2)[C:6]=1[F:17])[OH:4]

Komponenten

5

Edukt 3

HCID 10340Sodium CarbonateHCID 4311764Sodium borohydrideHCID 67532664HCID 67532664, Verbindung

Produkt 1

HCID 57448056HCID 57448056, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

2,2,2-trifluoro-1-(2-fluoro-3-piperidin-4-ylphenyl)ethanone (0.045 g, 0.16 mmol) was dissolved in ethanol (10 ml) and sodium borohydride (0.026 g, 0.064 mmol) was added. The resulting mixture was stirred for 24 h, after which aqueous sodium carbonate (10%, 20 ml) was added. The aqueous phase was extracted with ethylacetate (3×20 ml) and the combined organic phases was dried (MgSO4), filtered and evaporated to dryness. Yield: 0.03 g. MS m/z (rel. intensity, 70 eV) 277 (M+, 87), 276 (69), 178 (14), 103 (19), 56 (bp).

Aufarbeitung

  1. extractionThe aqueous phase was extracted with ethylacetate (3×20 ml)
  2. dry with materialthe combined organic phases was dried (MgSO4)
  3. filtrationfiltered
  4. customevaporated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-604700d3ce15492ba859edc2b48ccb50
Quelldatensatz
uspto-grants-2012_11
Patentnummer
US08314126B2

Notizen zur Reaktion

Wird geladen…