[C:1]([C@@H:5]1[NH:29][CH2:28][CH2:27][CH2:26][CH2:25][CH:24]=[CH:23][C:22]2[CH:30]=[C:18]([CH:19]=[CH:20][CH:21]=2)[C:17]2=[CH:31][C:13](=[CH:14][CH:15]=[CH:16]2)[CH2:12][O:11][C@H:10]2[CH2:32][N:7]([C@H:8]([C:33]([O:35][CH3:36])=[O:34])[CH2:9]2)[C:6]1=[O:37])([CH3:4])([CH3:3])[CH3:2].FC(F)(F)C(O)=O>CO.[Pd]>[C:1]([C@@H:5]1[NH:29][CH2:28][CH2:27][CH2:26][CH2:25][CH2:24][CH2:23][C:22]2[CH:30]=[C:18]([CH:19]=[CH:20][CH:21]=2)[C:17]2=[CH:31][C:13](=[CH:14][CH:15]=[CH:16]2)[CH2:12][O:11][C@H:10]2[CH2:32][N:7]([C@H:8]([C:33]([O:35][CH3:36])=[O:34])[CH2:9]2)[C:6]1=[O:37])([CH3:4])([CH3:2])[CH3:3]Pd/C 10% (20% w/w) was added to a 0.025 M solution of methyl (9R,11S,14S,20E)-14-tert-butyl-13-oxo-8-oxa-12,15-diazatetracyclo[20.3.1.12,6.1 9,12]octacosa-1(26),2(28),3,5,20,22,24-heptaene-11-carboxylate 103 in MeOH containing trifluoroacetic acid (1.0 eq.). The reaction mixture was stirred under a hydrogen atmosphere for 6 h. Solids were filtered off and the resulting solution was evaporated under reduced pressure. The residue was used without further purification in the following step. MS (ES+) m/z 507 (M+H)+.
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