Glyoxal → 1-(1-ethyl-4-hydroxy-1H-pyrazol-3-yl)ethanone
Reaktionsgleichung
[CH:1]([CH:3]=O)=[O:2].[CH2:5]([NH:7][N:8]=[CH:9][C:10](=[O:12])[CH3:11])[CH3:6]>O>[CH2:5]([N:7]1[CH:11]=[C:10]([OH:12])[C:9]([C:1](=[O:2])[CH3:3])=[N:8]1)[CH3:6]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
A 40% aqueous solution of glyoxal (2.3 g, 1.8 mL, 16 mmol) was added to a solution of 2-oxopropanal ethylhydrazone (1.83 g, 16 mmol) in water (90 mL). The mixture was heated at reflux for 1 hour. The reaction was cooled to room temperature and extracted with CH2Cl2 (4×). The combined organic extracts were dried over Na2SO4, filtered and concentrated to afford 1-(1-ethyl-4-hydroxy-1H-pyrazol-3-yl)ethanone as a yellow oil (2.16 g, 87%).
Aufarbeitung
- temperatureThe mixture was heated
- temperatureat reflux for 1 hour
- extractionextracted with CH2Cl2 (4×)
- dry with materialThe combined organic extracts were dried over Na2SO4
- filtrationfiltered
- concentrationconcentrated
Quellen und Nachweise
- ORD-Eintrag
- ord-2e719044d4cf4707bcbd923381baa437
- Quelldatensatz
- uspto-grants-2012_11
- Patentnummer
- US08318762B2
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