4-[1-(Trifluoromethyl)ethenyl]pyridine → 4-(2,2,2-Trifluoro-1-methyl-ethyl)pyridine

HRID 1880771

Reaktionsgleichung

Reaktionsgleichung von HRID 1880771
[F:1][C:2]([F:12])([F:11])[C:3]([C:5]1[CH:10]=[CH:9][N:8]=[CH:7][CH:6]=1)=[CH2:4].[H][H]>[Pd].C(OCC)(=O)C>[F:12][C:2]([F:1])([F:11])[CH:3]([C:5]1[CH:10]=[CH:9][N:8]=[CH:7][CH:6]=1)[CH3:4]

Komponenten

5

Edukt 2

HCID 595703554-[1-(Trifluoromethyl)ethenyl]pyridineHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 595703374-(2,2,2-Trifluoro-1-methyl-ethyl)pyridineAusbeute 85,7 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

To 20 ml of ethyl acetate were added 1.5 g of 4-[1-(trifluoromethyl)ethenyl]pyridine and 0.15 g of 10% Pd/C, and the mixture was stirred under the hydrogen atmosphere for 7 hours. The mixture was filtered, the filtrate was concentrated, and the residue was subjected to silica gel column chromatography to obtain 1.3 g of 4-(2,2,2-trifluoro-1-methyl-ethyl)pyridine.

Aufarbeitung

  1. filtrationThe mixture was filtered
  2. concentrationthe filtrate was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-3931ff0361f24cb786007c5b926220fa
Quelldatensatz
uspto-grants-2012_11
Patentnummer
US08318776B2

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