4-[1-(Trifluoromethyl)ethenyl]pyridine → 4-(2,2,2-Trifluoro-1-methyl-ethyl)pyridine
Reaktionsgleichung
[F:1][C:2]([F:12])([F:11])[C:3]([C:5]1[CH:10]=[CH:9][N:8]=[CH:7][CH:6]=1)=[CH2:4].[H][H]>[Pd].C(OCC)(=O)C>[F:12][C:2]([F:1])([F:11])[CH:3]([C:5]1[CH:10]=[CH:9][N:8]=[CH:7][CH:6]=1)[CH3:4]Komponenten
5
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
To 20 ml of ethyl acetate were added 1.5 g of 4-[1-(trifluoromethyl)ethenyl]pyridine and 0.15 g of 10% Pd/C, and the mixture was stirred under the hydrogen atmosphere for 7 hours. The mixture was filtered, the filtrate was concentrated, and the residue was subjected to silica gel column chromatography to obtain 1.3 g of 4-(2,2,2-trifluoro-1-methyl-ethyl)pyridine.
Aufarbeitung
- filtrationThe mixture was filtered
- concentrationthe filtrate was concentrated
Quellen und Nachweise
- ORD-Eintrag
- ord-3931ff0361f24cb786007c5b926220fa
- Quelldatensatz
- uspto-grants-2012_11
- Patentnummer
- US08318776B2
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