2-Hydroxy-5-nitroindane → 5-amino-2,3-dihydro-1H-inden-2-ol

HRID 1881354Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1881354
[N+:1]([C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[CH2:9][CH:8]([OH:13])[CH2:7]2)([O-])=O>[Pd]>[NH2:1][C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[CH2:9][CH:8]([OH:13])[CH2:7]2

Komponenten

3

Edukt 1

HCID 36859272-Hydroxy-5-nitroindane

Produkt 1

HCID 215550315-amino-2,3-dihydro-1H-inden-2-ol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 23938PalladiumKatalysator

Versuchsvorschrift

5-nitro-indan-2-ol (450 mg, 2.5 mmol) was hydrogenated using Pd/C (10%, dry, 100 mg) and H2 balloon at 1 atm at room temperature. Pd/C was filtered off through a pad of celite and the mother liquid was concentrated to give the crude product, 5-Amino-indan-2-ol.

Aufarbeitung

  1. customat room temperature
  2. filtrationPd/C was filtered off through a pad of celite
  3. concentrationthe mother liquid was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-c1e9be6881714f089dafe369bae5c784
Quelldatensatz
uspto-grants-2012_11
Patentnummer
US08318790B2

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