Phenol → Acetic acid, 2-phenoxy-, ethyl ester

HRID 18817

Reaktionsgleichung

Reaktionsgleichung von HRID 18817
[C:1]1([OH:7])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(=O)([O-])[O-].[K+].[K+].Br[CH2:15][C:16]([O:18][CH2:19][CH3:20])=[O:17].CCOCC>CN(C=O)C>[CH2:19]([O:18][C:16](=[O:17])[CH2:15][O:7][C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)[CH3:20]

Komponenten

6

Edukt 4

HCID 996PhenolHCID 3283Diethyl EtherHCID 7748Ethyl bromoacetateHCID 11430Potassium Carbonate

Produkt 1

HCID 17365Acetic acid, 2-phenoxy-, ethyl esterAusbeute 94,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Reaktionsbedingungen

Temperatur
70 °C

Versuchsvorschrift

To a solution of phenol (1.88 g, 20.0 mmol) in DMF (40 mL) is added potassium carbonate (3.03 g, 22.0 mmol) and ethyl bromoacetate (2.34 mL, 21.0 mmol), and the mixture is stirred at 70° C. for 18 h. The mixture is cooled to RT, Et2O is added, and the mixture is washed with water, brine, then dried (MgSO4), and filtered. The filtrate is evaporated, and the residue is vacuum distilled to give 3.39 g of the product 430.

Aufarbeitung

  1. temperatureThe mixture is cooled to RT
  2. washthe mixture is washed with water, brine
  3. dry with materialdried (MgSO4)
  4. filtrationfiltered
  5. customThe filtrate is evaporated
  6. distillationdistilled

Quellen und Nachweise

ORD-Eintrag
ord-02525e846e0e4b539bc293ebb0da1661
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07741493B2

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