Betamethasone → Cortisone
Reaktionsgleichung
C[C@@H:2]1[C@:19]([OH:28])([C:20]([CH2:22][O:23]P([O-])([O-])=O)=[O:21])[C@:18]2([CH3:29])[C@H:4]([C@H:5]3[C@:15](F)([C@@H:16]([OH:30])[CH2:17]2)[C@:14]2([CH3:32])[C:8](=[CH:9][C:10]([CH:12]=[CH:13]2)=[O:11])[CH2:7][CH2:6]3)[CH2:3]1.[Na+].[Na+].C[C@@H]1[C@](O)(C(CO)=O)[C@]2(C)[C@H]([C@H]3[C@](F)([C@@H](O)C2)[C@]2(C)C(=CC(C=C2)=O)CC3)C1>>[CH3:32][C@@:14]12[C@H:15]3[C:16]([CH2:17][C@:18]4([CH3:29])[C@@:19]([OH:28])([C:20]([CH2:22][OH:23])=[O:21])[CH2:2][CH2:3][C@H:4]4[C@@H:5]3[CH2:6][CH2:7][C:8]1=[CH:9][C:10](=[O:11])[CH2:12][CH2:13]2)=[O:30]Komponenten
3
Versuchsvorschrift
Eight rabbits of the New Zealand breed were used, weighing approximately 2 kg. In the right eye of each animal, 0.8 ml/week of Bentelan Depot (equivalent to 4 mg betametasone) were instilled for 4 weeks. The left eye was kept as control. The medicament, administered subconjunctivally, brought about an increase of the intraocular tension in the first week, reached its peak in the second week and then remained constant until the fifth week.
Aufarbeitung
- temperaturean increase of the intraocular tension in the first week
- customremained constant until the fifth week