Pregna-1,4-dien-3,20-dion, 9-Fluor-11,17-dihydroxy-16-methyl-21-(phosphonooxy)-, Dinatriumsalz, (11β,16β)-

Betamethasone Sodium Phosphate

HCID 65478CAS 151-73-5

Grundinformationen

Standard-SMILES
C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)COP(=O)([O-])[O-].[Na+].[Na+]
InChIKey
PLCQGRYPOISRTQ-LWCNAHDDSA-L
Summenformel
C22H28FNa2O8P
Durchschnittliche Molmasse
516,4 g/mol
Monoisotopische Masse
516,13012157

Namen und Bezeichner

Bevorzugter Name
Betamethasone Sodium Phosphate
IUPAC
disodium;[2-[(8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] phosphate
Lokaler Name
Pregna-1,4-dien-3,20-dion, 9-Fluor-11,17-dihydroxy-16-methyl-21-(phosphonooxy)-, Dinatriumsalz, (11β,16β)-
Englischer Name
Betamethasone 21-phosphate disodium
Summenformel
C22H28FNa2O8P
Molmasse
516.4

Namen und Synonyme

151-73-5Betamethasone sodium phosphateBetamethasone disodium phosphateBetamethasone 21-disodium phosphateBetamethasone 21-phosphate disodiumBetamethasone 21-phosphate disodium saltBetamethazone disodium phosphateDTXSID80471377BK02SCL3W9-Fluoro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 21-(disodium phosphate)NSC-90616CHEBI:3078
Weitere Namen anzeigen
DurabetasonbetnesolbentelanCelestanBentalanNSC 90616Vista-Methasone
DTXCID6027137Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-21-(phosphonooxy)-, disodium salt, (11beta,16beta)-betamethason sodium phosphateVistamethasoneBetam-ophtalVistamethasone nNSC90616RefChem:54528

Datenbank-Bezeichner

CAS
151-73-5
PubChem CID
65478
DTXSID
DTXSID8047137
ChEMBL
CHEMBL1200762
ChEBI
CHEBI:3078
UNII
7BK02SCL3W
EC Number
205-797-0
Nikkaji
J7.409H

Eigenschaften

Berechnete Struktureigenschaften

Polarare Oberfläche (TPSA)
147 Ų
H-Brücken-Donoren
2
H-Brücken-Akzeptoren
9
Frei drehbare Bindungen
3
Schwere Atome
34

Physikochemische Eigenschaften

Schmelzpunkt
206 · 206-211°C
storage temp.
room temp
Löslichkeit
Freely soluble in water, slightly soluble in ethanol (96 per cent), practically insoluble in methylene chloride.
Aggregatzustand
Solid
Farbe
White to Off-White
PH
7.5 · 7.5~9.0(5g/l, 25℃)

Sicherheit und Regulatorisches

GHS-Klassifizierung

GHS Classification · 5 Einträge

Danger

H302 (44.2%): Harmful if swallowed [Warning Acute toxicity, oral];H330 (54.9%): Fatal if inhaled [Danger Acute toxicity, inhalation];H360 (42.5%): May damage fertility or the unborn child [Danger Reproductive toxicity];H360D (15%): May damage the unborn child [Danger Reproductive toxicity];H372 (48.7%): Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure];H373 (12.4%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure];H410 (46.9%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]

P203, P260, P264, P270, P271, P273, P280, P284, P301+P317, P304+P340, P316, P318, P319, P320, P330, P391, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 113 reports by companies from 13 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.;Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

Gefahrenhinweise

Regulatory InformationBetamethasone sodium phosphate: Does not have an individual approval but may be used under an appropriate group standard
Other Safety Information · 1 Eintrag

IMAP assessments - Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-21-(phosphonooxy)-, disodium salt, (11.beta.,16.beta.)-: Environment tier I assessment;IMAP assessments - Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-21-(phosphonooxy)-, disodium salt, (11.beta.,16.beta.)-: Human health tier I assessment

Hazard Classes and CategoriesAcute Tox. 4 (44.2%);Acute Tox. 2 (54.9%);Repr. 1B (42.5%);Repr. 1B (15%);STOT RE 1 (48.7%);STOT RE 2 (12.4%);Aquatic Chronic 1 (46.9%)

Regulatorische Informationen

Regulatory InformationBetamethasone sodium phosphate: Does not have an individual approval but may be used under an appropriate group standard

Sicherheitsdaten

wgk
3
hs_code
29372290
RTECS-Nr.
TU4056500
risk_code
22
Toxizität
LD50 orl-rat: 1877 mg/kg DRUGAY -,1075,90
hazard_code
Xn

Chemie und Industrie

Pharmakologische Informationen

MeSH Pharmacological Classification · 1 Eintrag

A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system.

Verwendung und Herstellung

Use ClassificationAnimal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients

Anbieter50 Anbieter

北京华美互利生物化工010-56205725 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
合肥翰刚医药科技有限公司+8618062405514 · [email protected]
广州隽沐生物科技股份有限公司020-36607679; 13502246435 · [email protected]

Ergänzende Hinweise

DefinitionChEBI: An organic sodium salt that is the disodium salt of betamethasone phosphate.

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