6-(2-Pyrimidinyl)-5-hexynol → 6-(Pyrimidin-2-YL)hexan-1-OL

HRID 1886012Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1886012
[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[C:7]#[C:8][CH2:9][CH2:10][CH2:11][CH2:12][OH:13]>C(O)C.[Pd]>[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][OH:13]

Komponenten

4

Edukt 1

HCID 198767486-(2-Pyrimidinyl)-5-hexynol

Produkt 1

HCID 198767736-(Pyrimidin-2-YL)hexan-1-OLAusbeute 29,4 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel2×

Versuchsvorschrift

A solution of 6-(2-pyrimidinyl)-5-hexynol (3.09 g) in ethanol (100 ml) was added to a pre-hydrogenated suspension of 10% palladium on charcoal (1.05 g) in ethanol (50 ml) and hydrogenated at room temperature and pressure, filtered and evaporated in vacuo. The residual oil was purified by FCC eluting with ether and System C (99:1-85:15) to give the title compound as a pale yellow oil (0.93 g).

Aufarbeitung

  1. filtrationpressure, filtered
  2. customevaporated in vacuo
  3. customThe residual oil was purified by FCC
  4. washeluting with ether and System C (99:1-85:15)

Quellen und Nachweise

ORD-Eintrag
ord-4ab2a6f5eed9480ca3382287c4069849
Quelldatensatz
uspto-grants-1992_09
Patentnummer
US05149698

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