6-(Pyrimidin-5-YL)hex-5-YN-1-OL → 6-(Pyrimidin-5-yl)hexan-1-ol

HRID 1886013Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1886013
[N:1]1[CH:6]=[C:5]([C:7]#[C:8][CH2:9][CH2:10][CH2:11][CH2:12][OH:13])[CH:4]=[N:3][CH:2]=1>C(O)C.[Pd]>[N:1]1[CH:6]=[C:5]([CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][OH:13])[CH:4]=[N:3][CH:2]=1

Komponenten

4

Edukt 1

HCID 139997526-(Pyrimidin-5-YL)hex-5-YN-1-OL

Produkt 1

HCID 135575446-(Pyrimidin-5-yl)hexan-1-olAusbeute 93,9 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel2×

Versuchsvorschrift

A solution of 6-(5-pyrimidinyl)-5-hexynol (3.52 g) in ethanol (20 ml) was added to a pre-hydrogenated suspension of 10% palladium on carbon (1 g) in ethanol (130 ml) and hydrogenated at room temperature and pressure. The mixture was filtered through hyflo and the filtrate evaporated in vacuo to give the title compound as a pale yellow oil (3.38 g).

Aufarbeitung

  1. filtrationThe mixture was filtered through hyflo
  2. customthe filtrate evaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-05cc9a89d0ca4e758c1a8d4f93b9f13c
Quelldatensatz
uspto-grants-1992_09
Patentnummer
US05149698

Notizen zur Reaktion

Wird geladen…