[6-[(6-Bromohexyl)oxy]-1-hexynyl]pyrazine → [6-[(6-Bromohexyl)oxy]hexyl]pyrazine

HRID 1886028Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1886028
[Br:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][O:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]#[C:14][C:15]1[CH:20]=[N:19][CH:18]=[CH:17][N:16]=1>C(O)C.[Pd]>[Br:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][O:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][C:15]1[CH:20]=[N:19][CH:18]=[CH:17][N:16]=1

Komponenten

4

Edukt 1

HCID 19876775[6-[(6-Bromohexyl)oxy]-1-hexynyl]pyrazine

Produkt 1

HCID 19876745[6-[(6-Bromohexyl)oxy]hexyl]pyrazineAusbeute 87,7 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel2×

Versuchsvorschrift

A solution of [6-[(6-bromohexyl)oxy]-1-hexynyl]pyrazine (2.76 g) in ethanol (70 ml) was added to a pre-hydrogenated suspension of 10% palladium on carbon (2.00 g) in ethanol (50 ml) and hydrogenated at room temperature and pressure for 11 h. The mixture was filtered through hyflo and evaporated in vacuo to afford the title compound as a colourless oil (2.45 g), t.l.c. (ether) Rf 0.55.

Aufarbeitung

  1. filtrationThe mixture was filtered through hyflo
  2. customevaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-63bc457d41ff46f29a159da37cc68b84
Quelldatensatz
uspto-grants-1992_09
Patentnummer
US05149698

Notizen zur Reaktion

Wird geladen…