Sodium Hydroxide → HCID 19876826, Verbindung

HRID 1886039Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1886039
CS([C:5]1[N:9]([CH3:10])[C:8]2[CH:11]=[CH:12][CH:13]=[CH:14][C:7]=2[N:6]=1)(=O)=O.[C:15]([NH:18][CH2:19][CH2:20][NH2:21])(=[O:17])[CH3:16].[OH-].[Na+]>O>[CH3:10][N:9]1[C:8]2[CH:11]=[CH:12][CH:13]=[CH:14][C:7]=2[N:6]=[C:5]1[NH:21][CH2:20][CH2:19][NH:18][C:15](=[O:17])[CH3:16]

Komponenten

5

Edukt 3

HCID 14798Sodium HydroxideHCID 66082N-(2-aminoethyl)acetamideHCID 6407151H-benzimidazole, 1-methyl-2-(methylsulfonyl)-

Produkt 1

HCID 19876826HCID 19876826, VerbindungAusbeute 30 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A mixture of 2-methylsulfonyl-1-methyl-1H-benzimidazole (7.0 g, 0.033 mol) and N-acetylethylenediamine (17.0 g, 0.167 mol) was heated at 120°-125° C. for 8 hours. The mixture was cooled, diluted with H2O, made basic (pH8) with 2.5N NaOH, and filtered. The filtrate was extracted with EtOAc, and the combined extracts were washed with brine, dried, and concentrated to give a yellow solid 2.3 g (30%).

Aufarbeitung

  1. temperaturewas heated at 120°-125° C. for 8 hours
  2. temperatureThe mixture was cooled
  3. filtrationfiltered
  4. extractionThe filtrate was extracted with EtOAc
  5. washthe combined extracts were washed with brine
  6. customdried
  7. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-30c1f321743f4c65893aa24b4c8df49f
Quelldatensatz
uspto-grants-1992_09
Patentnummer
US05149700

Notizen zur Reaktion

Wird geladen…