Sodium Hydroxide → Bupivacaine (USAN:INN:BAN)

HRID 1886742

Reaktionsgleichung

Reaktionsgleichung von HRID 1886742
[CH3:1][CH2:2][CH2:3][CH2:4][N:5]1[CH:10]([C:11]([NH:13][C:14]2[C:15]([CH3:21])=[CH:16][CH:17]=[CH:18][C:19]=2[CH3:20])=[O:12])[CH2:9][CH2:8][CH2:7][CH2:6]1.Cl.[OH-].[Na+]>O>[CH3:1][CH2:2][CH2:3][CH2:4][N:5]1[CH:10]([C:11]([NH:13][C:14]2[C:15]([CH3:21])=[CH:16][CH:17]=[CH:18][C:19]=2[CH3:20])=[O:12])[CH2:9][CH2:8][CH2:7][CH2:6]1

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 64737Bupivacaine Hydrochloride

Produkt 1

HCID 2474Bupivacaine (USAN:INN:BAN)

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

Bupivacaine hydrochloride (Sigma-Aldrich Corporation, St. Louis, Mo.) was dissolved in de-ionized (DI) water at a concentration of 40 mg/ml (saturation). A calculated amount of sodium hydroxide (in the form of 1 N solution) was added to the solution and the pH of the final mixtures was adjusted to ten to precipitate the Bupivacaine base. The precipitated product was filtered, and further washed with DI water for at least three times. The precipitated product was dried at ca. 40° C. in vacuum for 24 hours.

Aufarbeitung

  1. customto precipitate the Bupivacaine base
  2. filtrationThe precipitated product was filtered
  3. washfurther washed with DI water for at least three times
  4. customThe precipitated product was dried at ca. 40° C. in vacuum for 24 hours

Quellen und Nachweise

ORD-Eintrag
ord-810d63d043b34203ab16d47ebf78540b
Quelldatensatz
uspto-grants-2013_08
Patentnummer
US08501215B2

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