4,5-difluoro-N-methyl-2-nitrobenzamide → HCID 57974170, Verbindung

HRID 1887699Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1887699
[F:1][C:2]1[C:11]([F:12])=[CH:10][C:5]([C:6]([NH:8][CH3:9])=[O:7])=[C:4]([N+:13]([O-])=O)[CH:3]=1.[H][H]>CO.[Pd]>[NH2:13][C:4]1[CH:3]=[C:2]([F:1])[C:11]([F:12])=[CH:10][C:5]=1[C:6]([NH:8][CH3:9])=[O:7]

Komponenten

5

Edukt 2

HCID 619939344,5-difluoro-N-methyl-2-nitrobenzamideHCID 178418361HCID 178418361, Verbindung2×

Produkt 1

HCID 57974170HCID 57974170, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

To 4,5-difluoro-N-methyl-2-nitrobenzamide (1.33 g, 6.15 mmol) in methanol (50 mL) was added Pd/C (10% Pd in carbon, 200 mg, 15 wt %) under argon. A hydrogen balloon was used as hydrogen source. The reaction was stirred at room temperature overnight. The mixture was filtered through celite and the celite pad was washed several times. The solvent was removed the crude was purified by silica gel chromatography to obtain the desired product (quantitative yield).

Aufarbeitung

  1. filtrationThe mixture was filtered through celite
  2. washthe celite pad was washed several times
  3. customThe solvent was removed the crude
  4. customwas purified by silica gel chromatography

Quellen und Nachweise

ORD-Eintrag
ord-c3b9679742b84d70a16bb2de293a8d62
Quelldatensatz
uspto-grants-2013_08
Patentnummer
US08501763B2

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