Isopropylamine → N-isopropyl-2-nitrobenzenesulfonamide

HRID 1887709Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1887709
[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[S:10](Cl)(=[O:12])=[O:11])([O-:3])=[O:2].[CH:14]([NH2:17])([CH3:16])[CH3:15].CCN(CC)CC>CO>[CH:14]([NH:17][S:10]([C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=1[N+:1]([O-:3])=[O:2])(=[O:12])=[O:11])([CH3:16])[CH3:15]

Komponenten

5

Edukt 3

HCID 6363IsopropylamineHCID 8471TriethylamineHCID 155402-Nitrobenzenesulfonyl chloride

Produkt 1

HCID 4154456N-isopropyl-2-nitrobenzenesulfonamideAusbeute 63 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To the solution of 2-nitrobenzene-1-sulfonyl chloride (1.11 g, 5.0 mmol) in MeOH (30 mL) was added isopropylamine (0.85 mL, 2.0 eq) and Et3N (1.4 mL, 2.0 eq). The mixture was stirred overnight at room temperature. The solvent was removed and the crude was purified by silica gel chromatography to obtain the desired product N-isopropyl-2-nitrobenzenesulfonamide (0.774 g, isolated yield 63%).

Aufarbeitung

  1. customThe solvent was removed
  2. customthe crude was purified by silica gel chromatography

Quellen und Nachweise

ORD-Eintrag
ord-29352af446574d9ab7712363069a2ad9
Quelldatensatz
uspto-grants-2013_08
Patentnummer
US08501763B2

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