N-isopropyl-2-nitrobenzenesulfonamide → 2-Amino-N-isopropylbenzenesulfonamide

HRID 1887710Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1887710
[CH:1]([NH:4][S:5]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[N+:14]([O-])=O)(=[O:7])=[O:6])([CH3:3])[CH3:2].[H][H]>CO.[Pd]>[NH2:14][C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=1[S:5]([NH:4][CH:1]([CH3:3])[CH3:2])(=[O:7])=[O:6]

Komponenten

5

Edukt 2

HCID 4154456N-isopropyl-2-nitrobenzenesulfonamideHCID 178418361HCID 178418361, Verbindung2×

Produkt 1

HCID 167834652-Amino-N-isopropylbenzenesulfonamide

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

To N-isopropyl-2-nitrobenzenesulfonamide (774 mg) in methanol (50 mL) was added Pd/C (10% Pd in carbon, 150 mg, 19 wt %) under argon protection. A hydrogen balloon was used as the hydrogen source. The reaction was stirred at room temperature overnight. The mixture was filtered through celite and the celite pad was washed several times. The solvent was removed and the crude was purified by silica gel chromatography to obtain the desired product 2-amino-N-isopropylbenzenesulfonamide (quantitative yield).

Aufarbeitung

  1. filtrationThe mixture was filtered through celite
  2. washthe celite pad was washed several times
  3. customThe solvent was removed
  4. customthe crude was purified by silica gel chromatography

Quellen und Nachweise

ORD-Eintrag
ord-ad18248975df4150a1fb470bd327ec34
Quelldatensatz
uspto-grants-2013_08
Patentnummer
US08501763B2

Notizen zur Reaktion

Wird geladen…