Chloroacetyl chloride → 2-Chloro-N-methyl-N-(4-nitro-phenyl)-acetamide

HRID 1887714Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1887714
[Cl:1][CH2:2][C:3](Cl)=[O:4].[CH3:6][NH:7][C:8]1[CH:13]=[CH:12][C:11]([N+:14]([O-:16])=[O:15])=[CH:10][CH:9]=1.[OH-].[K+]>CCOC(C)=O.O>[Cl:1][CH2:2][C:3]([N:7]([CH3:6])[C:8]1[CH:9]=[CH:10][C:11]([N+:14]([O-:16])=[O:15])=[CH:12][CH:13]=1)=[O:4]

Komponenten

6

Edukt 3

HCID 6577Chloroacetyl chlorideHCID 7483N-Methyl-4-nitroanilineHCID 14797Potassium Hydroxide

Produkt 1

HCID 114361292-Chloro-N-methyl-N-(4-nitro-phenyl)-acetamide

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

Chloroacetyl chloride (1.05 mL, 13.1 mmol) is added in one portion to a biphasic mixture of N-methyl-4-nitroaniline (1.0 g, 6.57 mmol), KOH (1.11 g, 19.7 mmol) in 12 mL EtOAc and 12 mL H2O, cooled to 0° C. The resulting mixture is stirred at this temperature for 5 min, then the ice bath was removed and it was allowed to warm to RT. The reaction was stirred for an additional one hour at RT.

Aufarbeitung

  1. customthe ice bath was removed
  2. temperatureto warm to RT
  3. stirringThe reaction was stirred for an additional one hour at RT

Quellen und Nachweise

ORD-Eintrag
ord-7ea943c4ff404856983585c5322e5957
Quelldatensatz
uspto-grants-2013_08
Patentnummer
US08501763B2

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