Iodoethane → 3-Bromo-4-ethoxybenzyl alcohol

HRID 1888767Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1888767
[Br:1][C:2]1[CH:7]=[C:6]([CH2:8][OH:9])[CH:5]=[CH:4][C:3]=1[OH:10].I[CH2:12][CH3:13].C(=O)([O-])[O-].[K+].[K+]>C(O)C>[Br:1][C:2]1[CH:7]=[C:6]([CH2:8][OH:9])[CH:5]=[CH:4][C:3]=1[O:10][CH2:12][CH3:13]

Komponenten

5

Edukt 3

HCID 6340IodoethaneHCID 11430Potassium CarbonateHCID 1215942-Bromo-4-hydroxymethylphenol

Produkt 1

HCID 580476873-Bromo-4-ethoxybenzyl alcoholAusbeute 87,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of 2-bromo-4-(hydroxymethyl)phenol (3.00 g, 14.7 mmol), iodoethane (4.60 mL, 44.3 mmol) and potassium carbonate (6.12 g, 44.3 mmol) in ethanol (30 mL) was stirred at room temperature for 2 days. The obtained reaction mixture was filtered through celite, and the solvent was evaporated under reduced pressure. The residue was applied to silica gel chromatography (ethyl acetate). The solvent was evaporated under reduced pressure to give (3-bromo-4-ethoxyphenyl)methanol (2.98 g) as a white solid.

Aufarbeitung

  1. customThe obtained reaction mixture
  2. filtrationwas filtered through celite
  3. customthe solvent was evaporated under reduced pressure
  4. customThe solvent was evaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-825de0de19a44d139f4af8e76ce0f888
Quelldatensatz
uspto-grants-2013_08
Patentnummer
US08501804B2

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