Hydrochloric Acid → [5-(Methanesulfonyl)pyridin-2-yl]methanaminium chloride

HRID 1888829Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1888829
[CH3:1][S:2]([C:5]1[CH:6]=[CH:7][C:8]([C:11]#[N:12])=[N:9][CH:10]=1)(=[O:4])=[O:3].[ClH:13].[H][H]>CO.[Pd]>[ClH:13].[CH3:1][S:2]([C:5]1[CH:6]=[CH:7][C:8]([CH2:11][NH2:12])=[N:9][CH:10]=1)(=[O:4])=[O:3]

Komponenten

6

Edukt 3

HCID 313Hydrochloric AcidHCID 591699295-(Methylsulfonyl)pyridine-2-carbonitrileHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 66725223[5-(Methanesulfonyl)pyridin-2-yl]methanaminium chlorideAusbeute 89 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

5-(Methylsulfonyl)pyridine-2-carbonitrile (2.15 g, 11.8 mmol) was dissolved in methanol (230 ml). 6M HCl (1 ml) and 10% palladium on carbon (2.34 mg) were added and the mixture was stirred under an atmospheric pressure of hydrogen overnight. The catalyst was removed by filtration through celite and the solvent was evaporated, water was added and the solution was freeze-dried to afford the title compound as a yellow powder (2.34 g, 89%).

Aufarbeitung

  1. customThe catalyst was removed by filtration through celite
  2. customthe solvent was evaporated
  3. additionwater was added
  4. customthe solution was freeze-dried

Quellen und Nachweise

ORD-Eintrag
ord-7357e64aaf5d464b8a870f42cac42a69
Quelldatensatz
uspto-grants-2013_08
Patentnummer
US08501784B2

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