Sodium Dithionite → N-(2-amino-5-(pyrrolidin-1-yl)phenyl)benzamide

HRID 1888953

Reaktionsgleichung

Reaktionsgleichung von HRID 1888953
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:14][CH2:13][CH2:12][CH2:11]2)=[CH:6][C:5]=1[NH:15][C:16](=[O:23])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)([O-])=O.S(S([O-])=O)([O-])=O.[Na+].[Na+]>C(O)C>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:11][CH2:12][CH2:13][CH2:14]2)=[CH:6][C:5]=1[NH:15][C:16](=[O:23])[C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1

Komponenten

4

Edukt 2

HCID 24489Sodium DithioniteHCID 68518954HCID 68518954, Verbindung

Produkt 1

HCID 68515788N-(2-amino-5-(pyrrolidin-1-yl)phenyl)benzamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of N-(2-nitro-5-(pyrrolidin-1-yl)phenyl)benzamide and sodium hydrosulfite (9 mmol) (3 mmol) in ethanol (150 mL) was refluxed for 1 h. After cooled to room temperature, the mixture was extracted with ethyl acetate (50 mL×3). The combined organics were washed with brine, dried over anhydrous MgSO4, and concentrated in vacuum to give crude N-(2-amino-5-(pyrrolidin-1-yl)phenyl)benzamide.

Aufarbeitung

  1. temperaturewas refluxed for 1 h
  2. extractionthe mixture was extracted with ethyl acetate (50 mL×3)
  3. washThe combined organics were washed with brine
  4. dry with materialdried over anhydrous MgSO4
  5. concentrationconcentrated in vacuum

Quellen und Nachweise

ORD-Eintrag
ord-fe3a50b761b2486e891ea850d7875b51
Quelldatensatz
uspto-grants-2013_08
Patentnummer
US08501957B2

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