Sodium borohydride → Imidazo[1,2-b]pyridazin-6-ylmethanol
Reaktionsgleichung
[N:1]1[CH:2]=[CH:3][N:4]2[C:9]=1[CH:8]=[CH:7][C:6]([C:10](OC)=[O:11])=[N:5]2.[BH4-].[Na+]>C(O)C>[N:1]1[CH:2]=[CH:3][N:4]2[C:9]=1[CH:8]=[CH:7][C:6]([CH2:10][OH:11])=[N:5]2Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
To a solution of methyl imidazo[1,2-b]pyridazine-6-carboxylate (1-3) (891 mg, 5.03 mmol) in ethanol (25 mL) was added NaBH4 (420 mg, 11.1 mmol) at room temperature. The suspension was stirred at room temperature for 2 h. The reaction mixture was concentrated in vacuum. The residue was purified by chromatography on silica gel to afford the title compound (630 mg). MS (m/z): 150 (M+1)+
Aufarbeitung
- concentrationThe reaction mixture was concentrated in vacuum
- customThe residue was purified by chromatography on silica gel
Quellen und Nachweise
- ORD-Eintrag
- ord-f6d704006346421fb0d31680795d6601
- Quelldatensatz
- uspto-grants-2013_08
- Patentnummer
- US08507487B2
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