Hydrochloric Acid → (RS)-S-[4-({5-bromo-4-[(R)-(2-hydroxy-1,2-dimethylpropyl)amino]-pyrimidin-2-yl}amino)phenyl]-S-cyclopropyl-N-[2-(trimethylsilyl)ethylsulfonyl]-sulfoximide

Reaktionsgleichung

[Br:1][C:2]1[C:3]([NH:9][C@H:10]([CH3:15])[C:11]([CH3:14])([OH:13])[CH3:12])=[N:4][C:5](Cl)=[N:6][CH:7]=1.[NH2:16][C:17]1[CH:22]=[CH:21][C:20]([S:23]([CH:35]2[CH2:37][CH2:36]2)(=[N:25][S:26]([CH2:29][CH2:30][Si:31]([CH3:34])([CH3:33])[CH3:32])(=[O:28])=[O:27])=[O:24])=[CH:19][CH:18]=1.Cl>C(#N)C.O1CCOCC1.O>[Br:1][C:2]1[C:3]([NH:9][C@H:10]([CH3:15])[C:11]([OH:13])([CH3:14])[CH3:12])=[N:4][C:5]([NH:16][C:17]2[CH:22]=[CH:21][C:20]([S:23]([CH:35]3[CH2:37][CH2:36]3)(=[N:25][S:26]([CH2:29][CH2:30][Si:31]([CH3:33])([CH3:34])[CH3:32])(=[O:27])=[O:28])=[O:24])=[CH:19][CH:18]=2)=[N:6][CH:7]=1