Hydrochloric Acid → 2-Amino-2-methyl-3-prop-2-ynyloxy-propan-1-ol

HRID 1892047

Reaktionsgleichung

Reaktionsgleichung von HRID 1892047
[CH3:1][C:2]1([CH2:12][O:13]CC#C)[NH:6][C:5]2(CCC[CH2:8][CH2:7]2)[O:4][CH2:3]1.Cl>O>[NH2:6][C:2]([CH3:1])([CH2:3][O:4][CH2:5][C:7]#[CH:8])[CH2:12][OH:13]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 595654083-Methyl-3-prop-2-ynyloxymethyl-1-oxa-4-aza-spiro[4.5]decane

Produkt 1

HCID 595653842-Amino-2-methyl-3-prop-2-ynyloxy-propan-1-olAusbeute 102,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

3-Methyl-3prop-2-ynyloxymethyl-1-oxa-4-aza-spiro[4.5]decane (1.83 g) in an aqueous solution of HCl (6N) (2.73 ml) were refluxed for 1 hr. The reaction mixture was cooled down to room temperature, diluted with water and extracted thrice with ethyl ether. The two layers were separated. The aqueous layer was concentrated under reduced pressure and further co-evaporated with toluene to yield 2-amino-2-methyl-3-prop-2-ynyloxy-propan-1-ol hydrochloric salt (1.205 g) as a white beige solid which was used in the next step without any further purification.

Aufarbeitung

  1. extractionextracted thrice with ethyl ether
  2. customThe two layers were separated
  3. concentrationThe aqueous layer was concentrated under reduced pressure and further co-evaporated with toluene

Quellen und Nachweise

ORD-Eintrag
ord-4a2ffbaad6f44822a495c36fe6bd05f5
Quelldatensatz
uspto-grants-2013_08
Patentnummer
US08507509B2

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