Ethanol → 2-methyl-5H,6H,7H,8H-imidazo(1,2-a)pyrazine

HRID 1893405

Reaktionsgleichung

Reaktionsgleichung von HRID 1893405
F[C:2](F)(F)[C:3]1[N:4]=[C:5]2[CH2:10][NH:9][CH2:8][CH2:7][N:6]2[CH:11]=1.ClCC(=O)C.C(O)C>[Pt](=O)=O.CO>[CH3:2][C:3]1[N:4]=[C:5]2[CH2:10][NH:9][CH2:8][CH2:7][N:6]2[CH:11]=1

Komponenten

6

Edukt 3

HCID 702EthanolHCID 6571ChloroacetoneHCID 147199282-(trifluoromethyl)-5H,6H,7H,8H-imidazo[1,2-a]pyrazine2×

Produkt 1

HCID 147199242-methyl-5H,6H,7H,8H-imidazo(1,2-a)pyrazine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 345198Adams' catalystKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

2-Methyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine was prepared in an analogous manner to that described above for 2-(trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine (Intermediate 4) but starting from 1-chloro-2-propanone instead of 3-bromo-1,1,1-trifluoro-2-propanone and using platinum (IV) oxide and ethanol in the place of 10% palladium on carbon paste and methanol for the hydrogenation step.

Quellen und Nachweise

ORD-Eintrag
ord-101a81792ae74a6e94f9801f7e91a112
Quelldatensatz
uspto-grants-2013_08
Patentnummer
US08513248B2

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