4-(2-tert-butyl-5-nitro-1H-pyrrole-4-carbonyl)-3,3-dimethylpiperazin-2-one → 4-(2-amino-5-tert-butyl-1H-pyrrole-3-carbonyl)-3,3-dimethylpiperazin-2-one

HRID 18937

Reaktionsgleichung

Reaktionsgleichung von HRID 18937
[C:1]([C:5]1[NH:6][C:7]([N+:21]([O-])=O)=[C:8]([C:10]([N:12]2[CH2:17][CH2:16][NH:15][C:14](=[O:18])[C:13]2([CH3:20])[CH3:19])=[O:11])[CH:9]=1)([CH3:4])([CH3:3])[CH3:2]>CO.[Pd]>[NH2:21][C:7]1[NH:6][C:5]([C:1]([CH3:4])([CH3:3])[CH3:2])=[CH:9][C:8]=1[C:10]([N:12]1[CH2:17][CH2:16][NH:15][C:14](=[O:18])[C:13]1([CH3:19])[CH3:20])=[O:11]

Komponenten

4

Edukt 1

HCID 586793674-(2-tert-butyl-5-nitro-1H-pyrrole-4-carbonyl)-3,3-dimethylpiperazin-2-one

Produkt 1

HCID 586792354-(2-amino-5-tert-butyl-1H-pyrrole-3-carbonyl)-3,3-dimethylpiperazin-2-one

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

To 4-(2-tert-butyl-5-nitro-1H-pyrrole-4-carbonyl)-3,3-dimethylpiperazin-2-one (120 mg) in methanol (10 mL) was added Pd catalyst (10% on carbon, 60 mg) and the resulting reaction mixture was stirred under H2 at 60 psi for overnight. After the solids were removed by filtration over Celite, the solvent was removed in vacuo to afford 4-(2-amino-5-tert-butyl-1H-pyrrole-3-carbonyl)-3,3-dimethylpiperazin-2-one 7 as a yellow film (100 mg, 92%).

Aufarbeitung

  1. customthe resulting reaction mixture
  2. customAfter the solids were removed by filtration over Celite
  3. customthe solvent was removed in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-51c3ecd5f60144d39cf31500a3d542e9
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07741479B2

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