Reaktionsgleichung
Cl.[C:2]([C:6]1[N:11]=[CH:10][C:9]([C:12]2[N:13]([C:33]([N:35]3[CH2:40][CH2:39][N:38]([CH2:41][C:42](O)=[O:43])[CH2:37][CH2:36]3)=[O:34])[C@@:14]([C:26]3[CH:31]=[CH:30][C:29]([Cl:32])=[CH:28][CH:27]=3)([CH3:25])[C@@:15]([C:18]3[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][CH:19]=3)([CH3:17])[N:16]=2)=[C:8]([O:45][CH2:46][CH3:47])[CH:7]=1)([CH3:5])([CH3:4])[CH3:3].[C:48]([NH2:52])([CH3:51])([CH3:50])[CH3:49]>>[C:48]([NH:52][C:42](=[O:43])[CH2:41][N:38]1[CH2:39][CH2:40][N:35]([C:33]([N:13]2[C@@:14]([C:26]3[CH:31]=[CH:30][C:29]([Cl:32])=[CH:28][CH:27]=3)([CH3:25])[C@@:15]([C:18]3[CH:19]=[CH:20][C:21]([Cl:24])=[CH:22][CH:23]=3)([CH3:17])[N:16]=[C:12]2[C:9]2[CH:10]=[N:11][C:6]([C:2]([CH3:3])([CH3:4])[CH3:5])=[CH:7][C:8]=2[O:45][CH2:46][CH3:47])=[O:34])[CH2:36][CH2:37]1)([CH3:51])([CH3:50])[CH3:49]Komponenten
3
Edukt 2
Produkt 1
Versuchsvorschrift
In a manner analogous to the method described in examples 99, {4-[(4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-acetic acid hydrochloride (example 94) was coupled with tert-butylamine (Aldrich) to give the title compound. HR-MS (ES, m/z) calculated for C39H51Cl2N6O3 [(M+H)+] 721.3394, observed 721.3399.
Quellen und Nachweise
- ORD-Eintrag
- ord-a26cc03eda7e46869d84ab1940550ef0
- Quelldatensatz
- uspto-grants-2013_08
- Patentnummer
- US08513239B2
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