HCID 67646998, Verbindung → 3-(1-(BOC-amino)-1-cyclopropyl-methyl)pyrrolidine

HRID 1895Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1895
[C:1]([NH:8][CH:9]([CH:13]1[CH2:17][CH2:16][N:15](CC2C=CC=CC=2)[CH2:14]1)[CH:10]1[CH2:12][CH2:11]1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2]>CO.[Pd]>[C:1]([NH:8][CH:9]([CH:13]1[CH2:17][CH2:16][NH:15][CH2:14]1)[CH:10]1[CH2:11][CH2:12]1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2]

Komponenten

4

Edukt 1

HCID 67646998HCID 67646998, Verbindung

Produkt 1

HCID 196914723-(1-(BOC-amino)-1-cyclopropyl-methyl)pyrrolidineAusbeute 35,1 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A sample (548 mg) of the compound from step 470d was dissolved in methanol, 140 mg of 10% Pd/C was added, and the mixture was hydrogenated at 4 atm H2 for 42 hours at room temperature. The solution was filtered, and the solvent was removed to give 140 mg of the title compound.

Aufarbeitung

  1. filtrationThe solution was filtered
  2. customthe solvent was removed

Quellen und Nachweise

ORD-Eintrag
ord-599ef965de604788a8f4493886ac4c46
Quelldatensatz
uspto-grants-1998_03
Patentnummer
US05726182

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