3-Fluoro-4-nitroanisole → 2-{3-[1-(5-Methoxy-2-nitrophenyl)piperidin-4-ylidene]prop-1-ynyl}-6-methylpyridine

Beteiligte Stoffe

Reaktionsschritte

A well homogenised mixture of the Compound of Example 3 (20 mg, 0.93 mmol) and 2-fluoro-4-methoxynitrobenzene (21.3 mg, 0.12 mmol) was stirred at 120° C. for 0.5 h. The reaction crude was purified by flash chromatography (EtOAc—Petroleum Ether 1:1) affording the title product (21 mg).

Herkunft & Nachweise