Hydrochloric Acid → HCID 16788087, Verbindung

HRID 1896015Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1896015
[OH-].[K+].[N+:3]([C:6]1[C:7]([N:12]2[CH2:17][CH2:16][CH:15]([C:18]([O:20]CC)=[O:19])[CH2:14][CH2:13]2)=[N:8][CH:9]=[CH:10][CH:11]=1)([O-:5])=[O:4].Cl>CO.O>[N+:3]([C:6]1[C:7]([N:12]2[CH2:17][CH2:16][CH:15]([C:18]([OH:20])=[O:19])[CH2:14][CH2:13]2)=[N:8][CH:9]=[CH:10][CH:11]=1)([O-:5])=[O:4]

Komponenten

6

Edukt 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 60631682HCID 60631682, Verbindung

Produkt 1

HCID 16788087HCID 16788087, VerbindungAusbeute 134,6 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 962WaterLösungsmittel2×

Versuchsvorschrift

To a solution of KOH (0.46 g, 8.16 mmol) in methanol (30 mL) and water (30 mL) was added Compound 258a (1.14 g, 4.08 mmol). The solution was stirred at r.t. for 1.5 hours, poured into water, acidified with 2M HCl and extracted with EtOAc. The combined organic layers were washed with brine, dried on Na2SO4 and evaporated to dryness in vacuo to afford the title product (1.38 g).

Aufarbeitung

  1. extractionextracted with EtOAc
  2. washThe combined organic layers were washed with brine
  3. customdried on Na2SO4
  4. customevaporated to dryness in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-3a325d3a9a864dac870a7fcc5190a601
Quelldatensatz
uspto-grants-2013_08
Patentnummer
US08518916B2

Notizen zur Reaktion

Wird geladen…