Hydrochloride methanol → cis-1,2,3,4,4a,5,6,11b-Octahydro-7h-pyrido[3,4-d][2]benzazepin-7-one

HRID 1896141Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1896141
[O:1]=[C:2]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[C@H:6]2[CH2:13][CH2:14][N:15](C(OC(C)(C)C)=O)[CH2:16][C@H:5]2[CH2:4][NH:3]1.Cl.CO>C(OCC)C>[CH2:13]1[C@H:6]2[C@H:5]([CH2:4][NH:3][C:2](=[O:1])[C:8]3[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=32)[CH2:16][NH:15][CH2:14]1

Komponenten

4

Edukt 2

HCID 21893726Hydrochloride methanolHCID 67249978Tert-butyl cis-7-oxo-1,2,4,4a,5,6,7,11b-octahydro-3h-pyrido[3,4-d][2]benzazepine-3-carboxylate

Produkt 1

HCID 49763200cis-1,2,3,4,4a,5,6,11b-Octahydro-7h-pyrido[3,4-d][2]benzazepin-7-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

To a suspension of Example 180G in 400 mL of diethyl ether was added 80 mL of HCl/methanol (5/V) at 25° C. The mixture was stirred overnight. The solid formed was collected and dried to obtain the title compound as the hydrochloride salt.

Aufarbeitung

  1. customThe solid formed
  2. customwas collected
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-f3ca9d70d2ea425595ebc61e8fc93a30
Quelldatensatz
uspto-grants-2013_08
Patentnummer
US08518933B2

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