Methyl 5-Acetoxy-2-formyl-4-methoxycinnamate → Methyl 5-Acetoxy-2-formyl-4-methoxyhydrocinnamate

HRID 1898761Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1898761
[C:1]([O:4][C:5]1[C:6]([O:19][CH3:20])=[CH:7][C:8]([CH:17]=[O:18])=[C:9]([CH:16]=1)[CH:10]=[CH:11][C:12]([O:14][CH3:15])=[O:13])(=[O:3])[CH3:2]>[Pd].C(OCC)(=O)C>[C:1]([O:4][C:5]1[C:6]([O:19][CH3:20])=[CH:7][C:8]([CH:17]=[O:18])=[C:9]([CH:16]=1)[CH2:10][CH2:11][C:12]([O:14][CH3:15])=[O:13])(=[O:3])[CH3:2]

Komponenten

4

Edukt 1

HCID 53756943Methyl 5-Acetoxy-2-formyl-4-methoxycinnamate

Produkt 1

HCID 23372351Methyl 5-Acetoxy-2-formyl-4-methoxyhydrocinnamate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

A mixture of methyl 5-acetoxy-2-formyl-4-methoxycinnamate (10.8 g) and 10% palladium on carbon (3 g) in ethyl acetate (100 ml) is hydrogenated at 45 psi for about 18 hours and filtered. The filtrate is concentrated in vacuo and the residue purified by HPLC, eluting 50% ethyl acetate in hexanes, to give the desired product.

Aufarbeitung

  1. filtrationfiltered
  2. concentrationThe filtrate is concentrated in vacuo
  3. customthe residue purified by HPLC
  4. washeluting 50% ethyl acetate in hexanes

Quellen und Nachweise

ORD-Eintrag
ord-d02b5e2cb1c64e93bd705cc8158c50d1
Quelldatensatz
uspto-grants-1996_11
Patentnummer
US05571506

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