Dimethylformamide → 2-(D-Alanylmethyl)-5-methyl-2,3,6,7-tetrahydrofuro-[2,3-f]quinoline-7-one

2-(Carbobenzyloxy-β-alanyl]aminomethyl-5-methyl-2,3,6,7-tetrahydrofuro-[2,3-f]quinoline-7-one (2.61 g, 6.00 mmol) was dissolved in dimethylformamide (200 ml). To the obtained solution, 10% palladium-on-carbon (2.61 g) was added, followed by stirring at room temperature for 5 hours in the atmosphere of hydrogen. The reaction mixture was filtered, and the filtrate was condensed under reduced pressure. The resultant residue was dissolved in methanol (50 ml). To the obtained solution, 1.37 N-HCl--methanol (4.82 ml) was added at room temperature, followed by being submitted to a recrystallizing procedure using methanol ether to obtain 1.80 g of the title compound as pale yellow powdery crystals (88.8%).

1. filtrationThe reaction mixture was filtered
2. customcondensed under reduced pressure

ORD-Eintrag

ord-024c217bf1f7489b8a443e7808699a76

Quelldatensatz

uspto-grants-1996_11

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US05576324