C[O:2][C:3]1[CH:4]=[CH:5][C:6]([CH3:21])=[C:7]([NH:9][C:10](=[O:20])[C:11]([CH3:19])=[CH:12]C2C=CC=CC=2)[CH:8]=1.[Cl-].[Al+3].[Cl-].[Cl-].ClC1C=CC=CC=1>CCCCCC>[OH:2][C:3]1[CH:4]=[CH:5][C:6]([CH3:21])=[C:7]2[C:8]=1[CH:19]=[C:11]([CH3:12])[C:10](=[O:20])[NH:9]2N-(5-Methoxy-2-methylphenyl)α-methylcinnamamide (21.3 g, 75.8 mmol) and aluminum chloride (50.4 g, 378 mmol) were combined with chlorobenzene (158 ml), and heated in a bath at 125° C. for 45 minutes while stirring. After cooling, the mixture was poured into ice-water, to which hexane was added. Precipitated crystals were collected by filtration, and dissolved in chloroform-methanol (4:1). After drying and condensing, the resultant residue was washed with chloroform to obtain 12.22 g of the title compound as pale brown crystals (85.3%).
Wird geladen…
