3-Chloro-2-methyl-1-propene → 5-(2-Methyl-2-propenyl)oxy-3,8-dimethylcarbostyril
Reaktionsgleichung
[OH:1][C:2]1[CH:11]=[CH:10][C:9]([CH3:12])=[C:8]2[C:3]=1[CH:4]=[C:5]([CH3:14])[C:6](=[O:13])[NH:7]2.Cl[CH2:16][C:17]([CH3:19])=[CH2:18]>>[CH3:18][C:17](=[CH2:16])[CH2:19][O:1][C:2]1[CH:11]=[CH:10][C:9]([CH3:12])=[C:8]2[C:3]=1[CH:4]=[C:5]([CH3:14])[C:6](=[O:13])[NH:7]2Komponenten
3
Versuchsvorschrift
Reaction, post-treatment, and recrystallization (chloroform-n-hexane) were performed in a manner similar to that described in Reference Example 31 using 5-hydroxy-3,8-dimethylcarbostyril (3 g, 15.87 mmol) and 3-chloro-2-methyl-1-propene (1.58 g, 17.46 mmol). As a result, 3.48 g of the title compound was obtained as pale brown crystals (90.2%).
Aufarbeitung
- customReaction
- customrecrystallization (chloroform-n-hexane)