Tetrabutylammonium Fluoride → 4-(3-Pyrrolyl)-7-bromocoumarin

HRID 1901130Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1901130
[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([C:13]3[CH:17]=[CH:16][N:15]([Si](C(C)C)(C(C)C)C(C)C)[CH:14]=3)=[CH:7][C:8](=[O:12])[O:9]2)=[CH:4][CH:3]=1.[N+](CCCC)(CCCC)(CCCC)CCCC.[F-]>C1COCC1.CCOC(C)=O>[NH:15]1[CH:16]=[CH:17][C:13]([C:6]2[C:5]3[C:10](=[CH:11][C:2]([Br:1])=[CH:3][CH:4]=3)[O:9][C:8](=[O:12])[CH:7]=2)=[CH:14]1

Komponenten

5

Edukt 2

HCID 2724141Tetrabutylammonium FluorideHCID 23370193HCID 23370193, Verbindung

Produkt 1

HCID 233702084-(3-Pyrrolyl)-7-bromocoumarin

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 8028TetrahydrofuranLösungsmittel2×HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

To a solution of the silyl compound from Step 1 (42 mg, 0.094 mmol) in THF (1 mL) was added Bu4NF 1M in THF (94 (L, 0.094 mmol) and the reaction mixture was stirred at r.t. for 15 min. The mixture was diluted with EtOAc, washed with brine, dried over MgSO4, filtered and evaporated to give the title compound as an oil.

Aufarbeitung

  1. washwashed with brine
  2. dry with materialdried over MgSO4
  3. filtrationfiltered
  4. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-9f4ea5b90d4e413d8ac8e53754a6f40e
Quelldatensatz
uspto-grants-1996_11
Patentnummer
US05576338

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