Tetrabutylammonium Fluoride → 2-[5-(4-Methoxyphenoxymethyl)-2-oxooxazolidin-3-yl]propanol
Reaktionsgleichung
[Si]([O:8][CH2:9][CH:10]([N:12]1[CH2:16][CH:15]([CH2:17][O:18][C:19]2[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[CH:21][CH:20]=2)[O:14][C:13]1=[O:27])[CH3:11])(C(C)(C)C)(C)C.[F-].C([N+](CCCC)(CCCC)CCCC)CCC>O1CCCC1>[CH3:26][O:25][C:22]1[CH:21]=[CH:20][C:19]([O:18][CH2:17][CH:15]2[O:14][C:13](=[O:27])[N:12]([CH:10]([CH3:11])[CH2:9][OH:8])[CH2:16]2)=[CH:24][CH:23]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
A procedure similar to that described in Preparation 5(b) was repeated, except that 1.52 g of 3-(2-t-butyldimethylsilyloxy-1-methylethyl)-5-(4-methoxyphenoxymethyl)oxazolidin-2-one (less polar isomer), obtained as described in Preparation 76, 12 ml of tetrabutylammonium fluoride (26% w/v in tetrahydrofuran) and 10 ml of anhydrous tetrahydrofuran were used, to give 1.20 g of the title compound, melting at 80° C. to 88° C., from the less polar diastereomer.