Water → HCID 23368712, Verbindung

HRID 1901808Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1901808
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([NH:17][S:18]([C:21]2[CH:27]=[CH:26][C:24]([CH3:25])=[CH:23][CH:22]=2)(=[O:20])=[O:19])=[C:6]([CH:16]=1)[C:7]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[Cl:15])=[O:8].[H-].[Na+].[CH3:30]C(C)(Br)C(N)=O.O.[CH3:38][N:39]([CH:41]=[O:42])[CH3:40]>>[S:18]([N:17]([C:5]1[CH:4]=[CH:3][C:2]([Cl:1])=[CH:16][C:6]=1[C:7]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[Cl:15])=[O:8])[CH2:30][C:41](=[O:42])[N:39]([CH3:40])[CH3:38])([C:21]1[CH:22]=[CH:23][C:24]([CH3:25])=[CH:26][CH:27]=1)(=[O:19])=[O:20]

Komponenten

6

Edukt 5

HCID 962WaterHCID 6228DimethylformamideHCID 24758Sodium hydrideHCID 1012352-Bromo-2-methylpropanamideHCID 23368680N-[4-Chloro-2-(2-chlorobenzoyl)phenyl]-4-methylbenzene-1-sulfonamide

Produkt 1

HCID 23368712HCID 23368712, Verbindung

Versuchsvorschrift

8.4 g of 5,2'-dichloro-2-tosylaminobenzophenone are dissolved in 40 ml of DMF and treated with 0.7 g of 80% sodium hydride; after 15 minutes, 10 g of dimethylbromoacetamide, prepared in Example 1, are added and the mixture is stirred overnight at RT. The reaction medium is poured into water, the precipitate formed is filtered off and taken up with DCM and the solution is dried and concentrated. 9.2 g of the expected product are obtained after crystallization from isopropyl ether.

Aufarbeitung

  1. additionare added
  2. customthe precipitate formed
  3. filtrationis filtered off
  4. customthe solution is dried
  5. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-29acb750a2bd4746abf09d8eb740e933
Quelldatensatz
uspto-grants-1996_11
Patentnummer
US05578633

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