2,3-Dihydro-6-nitroimidazo(2,1-b)benzothiazole → 2,3-Dihydroimidazo(2,1-b)benzothiazol-6-amine

HRID 1902632Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1902632
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]2[S:11][C:10]3=[N:12][CH2:13][CH2:14][N:9]3[C:8]=2[CH:15]=1)([O-])=O.[H][H]>[Pd].CO>[N:12]1[CH2:13][CH2:14][N:9]2[C:8]3[CH:15]=[C:4]([NH2:1])[CH:5]=[CH:6][C:7]=3[S:11][C:10]=12

Komponenten

5

Edukt 2

HCID 128919642,3-Dihydro-6-nitroimidazo(2,1-b)benzothiazoleHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 6586872,3-Dihydroimidazo(2,1-b)benzothiazol-6-amine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of 11 parts of 2,3-dihydro-6-nitroimidazo[2,1-b]benzothiazole and 80 parts of methanol is hydrogenated at normal pressure and at room temperature with 5 parts of palladium-on-charcoal catalyst 10%. After the calculated amount of hydrogen is taken up, the catalyst is filtered off and the filtrate is evaporated. The residue is crystallized from dimethylbenzene. The product is filtered off and dried, yielding 5.6 parts of 2,3-dihydroimidazo[2,1-b]benzothiazol-6-amine; mp. 204°-210° C.

Aufarbeitung

  1. filtrationthe catalyst is filtered off
  2. customthe filtrate is evaporated
  3. customThe residue is crystallized from dimethylbenzene
  4. filtrationThe product is filtered off
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-0ed93e7ccc5147569caf7196be0e10fc
Quelldatensatz
uspto-grants-1982_12
Patentnummer
US04364942

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