Benzene → Diethyl 1-benzyl-4-oxoazetidine-2,2-dicarboxylate

HRID 1903014Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1903014
[CH2:1]([N:8]([CH:13]([C:19]([O:21][CH2:22][CH3:23])=[O:20])[C:14]([O:16][CH2:17][CH3:18])=[O:15])[C:9](=[O:12])[CH2:10]Cl)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(N(CC)CC)C.C1C=CC=CC=1.Cl>O>[CH2:1]([N:8]1[C:9](=[O:12])[CH2:10][C:13]1([C:19]([O:21][CH2:22][CH3:23])=[O:20])[C:14]([O:16][CH2:17][CH3:18])=[O:15])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

6

Edukt 4

HCID 241BenzeneHCID 313Hydrochloric AcidHCID 8471TriethylamineHCID 13505937HCID 13505937, Verbindung

Produkt 1

HCID 13505935Diethyl 1-benzyl-4-oxoazetidine-2,2-dicarboxylateAusbeute 75 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel2×

Versuchsvorschrift

34.1 g. (0.1 moles) of diethyl N-benzyl-N-(chloroacetyl)-amino-malonate prepared according to Example 19 and 18.2 ml. (13.2 g., 0.13 moles) of triethyl amine in 100 ml. of benzene are stirred at room temperature for 8 hours. The mixture is shaken with 100 ml. of water, 50 ml. of a 10% aqueous hydrochloric acid solution and again with 100 ml. of water. The organic phase is dried with magnesium sulfate, filtered and from the filtrate benzene is distilled off. The oily residue is distilled at 149° to 150° C., under a pressure of 0.1 mmHg. 23 g. (75%) of the named compound are obtained.

Aufarbeitung

  1. dry with materialThe organic phase is dried with magnesium sulfate
  2. filtrationfiltered and from the filtrate benzene
  3. distillationis distilled off
  4. distillationThe oily residue is distilled at 149° to 150° C., under a pressure of 0.1 mmHg

Quellen und Nachweise

ORD-Eintrag
ord-e326b14dd8a44215accfb5ea883d9eb2
Quelldatensatz
uspto-grants-1984_03
Patentnummer
US04435322

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