Acetone → 1-Benzyl-3-(4-chlorophenyl)urea

HRID 1903294

Reaktionsgleichung

Reaktionsgleichung von HRID 1903294
[SH2]=N.[CH2:3]([NH:10][C:11](C1C=CC=CC=1C(O)=O)=[O:12])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.O.CC(C)=O.[Cl:27][C:28]1[CH:34]=[CH:33][C:31]([NH2:32])=[CH:30][CH:29]=1>O.CC(C)=O.C(N(CC)CC)C>[Cl:27][C:28]1[CH:34]=[CH:33][C:31]([NH:32][C:11]([NH:10][CH2:3][C:4]2[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=2)=[O:12])=[CH:30][CH:29]=1

Komponenten

7

Edukt 4

HCID 180AcetoneHCID 962WaterHCID 78124-ChloroanilineHCID 178514672HCID 178514672, Verbindung

Produkt 1

HCID 7306671-Benzyl-3-(4-chlorophenyl)ureaAusbeute 82,5 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 8471TriethylamineLösungsmittelHCID 18366337Propan-2-one--water (1/1)Lösungsmittel

Versuchsvorschrift

6.32 g benzylcarbamoyl-benzoic acid sulfimide was suspended in 40 ml of a 1:1 mixture of water and aceton. 2.55 g p-chloroaniline was added to the suspension, then a solution of 2.8 ml triethylamine with 10 ml of a 1:1 water-aceton mixture was added dropwise at ambient temperature during a half hour. The reaction mixture was stirred for 5 hours at room temperature, the obtained product was evacuated, washed with a 1:1 mixture of water and aceton and dried. 4.3 g 1-(4-chlorophenyl)-3-benzylurea was obtained, which melted at 206°-208° C.

Aufarbeitung

  1. customthe obtained product was evacuated
  2. washwashed with a 1:1 mixture of water and aceton
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-5efef5cb173147bb960c573b60110af0
Quelldatensatz
uspto-grants-1984_03
Patentnummer
US04435567

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