Hydrochloric Acid → H-(D)Ala-Gly-OBzl.hydrochloride

HRID 1903866

Reaktionsgleichung

Reaktionsgleichung von HRID 1903866
[NH:1](C(OC(C)(C)C)=O)[C@@H:2]([C:4]([NH:6][CH2:7][C:8]([O:10][CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=[O:9])=[O:5])[CH3:3].[ClH:25].CCOCC>O1CCOCC1>[NH2:1][C@@H:2]([C:4]([NH:6][CH2:7][C:8]([O:10][CH2:11][C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1)=[O:9])=[O:5])[CH3:3].[ClH:25]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 15567200Boc-(D)Ala-Gly-OBzl

Produkt 1

HCID 131712174H-(D)Ala-Gly-OBzl.hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

3.4 g of Boc-(D)Ala-Gly-OBzl are dissolved in 50 ml of dioxane containing HCl and left to stand for one hour. The volume of the solution is reduced under vacuum and an excess of ether added. The precipitated salt is filtered off, dried and used as such for the coupling reaction.

Aufarbeitung

  1. waitleft
  2. filtrationThe precipitated salt is filtered off
  3. customdried
  4. customsuch for the coupling reaction

Quellen und Nachweise

ORD-Eintrag
ord-9f20d9343e204aba90facb8abb9f7130
Quelldatensatz
uspto-grants-1984_03
Patentnummer
US04438103

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