Boc-Tyr-(D)Ala-Gly-OBzl → Boc-tyr-D-ala-gly-OH

HRID 1903868Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1903868
[NH:1]([C:30]([O:32][C:33]([CH3:36])([CH3:35])[CH3:34])=[O:31])[C@H:2]([C:11]([NH:13][C@@H:14]([C:16]([NH:18][CH2:19][C:20]([O:22]CC1C=CC=CC=1)=[O:21])=[O:17])[CH3:15])=[O:12])[CH2:3][C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[CH:6][CH:5]=1>CO.O.[Pd]>[NH:1]([C:30]([O:32][C:33]([CH3:34])([CH3:36])[CH3:35])=[O:31])[C@H:2]([C:11]([NH:13][C@@H:14]([C:16]([NH:18][CH2:19][C:20]([OH:22])=[O:21])=[O:17])[CH3:15])=[O:12])[CH2:3][C:4]1[CH:5]=[CH:6][C:7]([OH:10])=[CH:8][CH:9]=1

Komponenten

4

Edukt 1

HCID 15567201Boc-Tyr-(D)Ala-Gly-OBzl

Produkt 1

HCID 7272028Boc-tyr-D-ala-gly-OH

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumLösungsmittelHCID 22242641Methanol--water (1/1)Lösungsmittel

Versuchsvorschrift

12 g of Boc-Tyr-(D)Ala-Gly-OBzl are dissolved in a mixture of methanol/H2O (9:1) and hydrogenated in the presence of Pd-C at normal pressure and room temperature. The mixture is filtered off from the catalyst, reduced in volume and crystallised from methanol/CH2Cl2 /ether. Decomp. 110°.

Aufarbeitung

  1. filtrationThe mixture is filtered off from the catalyst
  2. customcrystallised from methanol/CH2Cl2 /ether
  3. custom110°

Quellen und Nachweise

ORD-Eintrag
ord-bb05406f601f43229aaf95aec66b1c9d
Quelldatensatz
uspto-grants-1984_03
Patentnummer
US04438103

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