Ethyl 7-chloro-1H-pyrazolo[4,3-B]pyridine-6-carboxylate → ethyl 7-n-butylamino-1H-pyrazolo [4,3-b]pyridine-6-carboxylate

HRID 1904271

Reaktionsgleichung

Reaktionsgleichung von HRID 1904271
Cl[C:2]1[C:7]([C:8]([O:10][CH2:11][CH3:12])=[O:9])=[CH:6][N:5]=[C:4]2[CH:13]=[N:14][NH:15][C:3]=12>C(N)CCC>[CH2:4]([NH:5][C:2]1[C:7]([C:8]([O:10][CH2:11][CH3:12])=[O:9])=[CH:6][N:5]=[C:4]2[CH:13]=[N:14][NH:15][C:3]=12)[CH2:3][CH2:2][CH3:7]

Komponenten

3

Edukt 1

HCID 20038759Ethyl 7-chloro-1H-pyrazolo[4,3-B]pyridine-6-carboxylate

Produkt 1

HCID 20038776ethyl 7-n-butylamino-1H-pyrazolo [4,3-b]pyridine-6-carboxylateAusbeute 135,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8007ButylamineLösungsmittel

Versuchsvorschrift

Ethyl 7-chloro-1H-pyrazolo[4,3-b]pyridine-6-carboxylate (3.5 g, 15.5 mmol) was dissolved in n-butylamine (25 ml) and stirred at room temperature for 3 h. Excess butylamine was removed in vacuo and the residual solid was washed well with water, and recrystallised from ethyl acetate to give ethyl 7-n-butylamino-1H-pyrazolo [4,3-b]pyridine-6-carboxylate (2.75 g, 67%), m.p. 164°-170° C.

Aufarbeitung

  1. customExcess butylamine was removed in vacuo
  2. washthe residual solid was washed well with water
  3. customrecrystallised from ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-c7eda3542d964d179234801c23ff0d71
Quelldatensatz
uspto-grants-1989_06
Patentnummer
US04837238

Verknüpfte Notizen

Wird geladen…