Water → 31309-58-7

HRID 1906201Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1906201
Cl[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][N:4]=1.[CH3:9][NH:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.C(=O)([O-])[O-].[K+].[K+].O>CN(C)C=O>[CH3:9][N:10]([CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][N:4]=1)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

Komponenten

6

Edukt 4

HCID 962WaterHCID 7515N-MethylanilineHCID 11430Potassium CarbonateHCID 23393Picolyl chloride

Produkt 1

HCID 1421163431309-58-7Ausbeute 50,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Reaktionsbedingungen

Temperatur
120 °C

Versuchsvorschrift

A mixture of 2-chloromethylpyridine (50 g), N-methylaniline (42 g), and potassium carbonate (120 g) in N,N-dimethylformamide (200 ml) was stirred for 4 hours at 120° C. The reaction mixture was cooled to room temperature, added to water (1 l), and extracted with ether. The ether extract was washed with water and then treated with activated carbon. After drying over magnesium sulfate, the ether extract was filtered and concentrated. The residue was crystallized from isopropyl alcohol to give N-methyl-N-(2-pyridylmethyl)aniline (39 g).

Aufarbeitung

  1. temperatureThe reaction mixture was cooled to room temperature
  2. extractionextracted with ether
  3. extractionThe ether extract
  4. washwas washed with water
  5. additiontreated with activated carbon
  6. dry with materialAfter drying over magnesium sulfate
  7. extractionthe ether extract
  8. filtrationwas filtered
  9. concentrationconcentrated
  10. customThe residue was crystallized from isopropyl alcohol

Quellen und Nachweise

ORD-Eintrag
ord-bbfa271d7f044856993083f5cf71c13e
Quelldatensatz
uspto-grants-1987_03
Patentnummer
US04650804

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