Hydrochloric Acid → HCID 13826432, Verbindung

HRID 1906924Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1906924
[Cl:1][C:2]1[C:11]2[CH2:10][CH2:9][CH2:8][C:7](=[O:12])[C:6]=2[C:5]([CH2:13][CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16])=[C:4]([CH3:20])[CH:3]=1.Cl.S(Cl)([Cl:25])(=O)=O>C(Cl)Cl>[Cl:1][C:2]1[C:11]2[CH2:10][CH2:9][CH:8]([Cl:25])[C:7](=[O:12])[C:6]=2[C:5]([CH2:13][CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16])=[C:4]([CH3:20])[CH:3]=1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 24648Sulfuryl chlorideHCID 13826430HCID 13826430, Verbindung

Produkt 1

HCID 13826432HCID 13826432, VerbindungAusbeute 95,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A solution of ethyl 3-(4-chloro-2-methyl-8-oxo-5,6,7,8-tetrahydronaphthalen-1-yl)propanoate (5.70 g, 20.3 mmoles) in CH2Cl2 (20 ml) was saturated with dry gaseous HCl and sulfuryl chloride (16.4 ml, 27.5 g, 203 mmoles) was added dropwise and stirred at room temperature for 2 hours. The solvent and excess sulfuryl chloride were evaporated in vacuo then chased with dry toluene two times to leave 6.40 g of title compound as a gum. Exact mass calculated for C16H17O3Cl (parent-HCl): 292.0866; Found: 292.0869

Aufarbeitung

  1. additionwas added dropwise
  2. customThe solvent and excess sulfuryl chloride were evaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-066b2796f69e479896e5f6b8d87d4e6b
Quelldatensatz
uspto-grants-1987_03
Patentnummer
US04654363

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