Morpholine → HCID 53944659, Verbindung

HRID 1907706Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1907706
CS([C:5]1[N:10]=[CH:9][C:8]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:7][N:6]=1)(=O)=O.[NH:16]1[CH2:21][CH2:20][O:19][CH2:18][CH2:17]1>COCCOC.C(Cl)Cl>[O:19]1[CH2:20][CH2:21][N:16]([C:5]2[N:10]=[CH:9][C:8]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:7][N:6]=2)[CH2:17][CH2:18]1

Komponenten

5

Edukt 2

HCID 8083MorpholineHCID 254889Ethyl 2-(methylsulfonyl)pyrimidine-5-carboxylate

Produkt 1

HCID 53944659HCID 53944659, VerbindungAusbeute 108 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6344DichloromethaneLösungsmittelHCID 80711,2-DimethoxyethaneLösungsmittel

Versuchsvorschrift

A solution of sulfone 121 (0.184 g, 0.80 mmol) in ethyleneglycol dimethylether (5 mL) was treated with neat morpholine (0.3 mL, 3.4 mmol) and the mixture was stirred at room temperature for 48 h. The reaction mixture was then diluted with DCM and washed with saturated NaHCO3 in brine, dried over MgSO4, filtered, concentrated and stored under vacuum to give intermediate 122 (0.205 g, >99% yield).

Aufarbeitung

  1. washwashed with saturated NaHCO3 in brine
  2. dry with materialdried over MgSO4
  3. filtrationfiltered
  4. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-dcd232c1eff14adbb87198f411184f79
Quelldatensatz
uspto-grants-2013_12
Patentnummer
US08598168B2

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