2-Amino-1-(4-fluorophenyl)ethanone → 2-Amino-1-(4-fluorophenyl)ethan-1-ol

HRID 1908256

Reaktionsgleichung

Reaktionsgleichung von HRID 1908256
[NH2:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([F:11])=[CH:7][CH:6]=1)=[O:4].[BH4-].[Na+]>CO>[NH2:1][CH2:2][CH:3]([C:5]1[CH:10]=[CH:9][C:8]([F:11])=[CH:7][CH:6]=1)[OH:4]

Komponenten

4

Edukt 2

HCID 15811772-Amino-1-(4-fluorophenyl)ethanoneHCID 4311764Sodium borohydride

Produkt 1

HCID 98272-Amino-1-(4-fluorophenyl)ethan-1-olAusbeute 100 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution consisting of 2-amino-1-(4-fluoro-phenyl)-ethanone (150 mg, 0.9 mmol) and MeOH (5 mL) was added NaBH4 (97 mg, 2.6 mmol). The mixture was stirred at rt for 45 min and then concentrated to dryness. The residue was diluted with EtOAc and washed with a satd. NH4Cl solution before drying (Na2SO4), and concentrating to give 2-amino-1-(4-fluoro-phenyl)-ethanol (139 mg, 100%) which was used without further purification.

Aufarbeitung

  1. concentrationconcentrated to dryness
  2. additionThe residue was diluted with EtOAc
  3. washwashed with a satd
  4. dry with materialNH4Cl solution before drying (Na2SO4)
  5. concentrationconcentrating

Quellen und Nachweise

ORD-Eintrag
ord-3de15211aafd4142a970ccbc6622e103
Quelldatensatz
uspto-grants-2013_12
Patentnummer
US08598202B2

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