Hydrochloric Acid → HCID 53345566, Verbindung

HRID 1909094Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1909094
[F:1][C:2]([F:34])([F:33])[O:3][C:4]1[CH:32]=[CH:31][C:7]([O:8][CH:9]2[CH2:14][CH2:13][N:12]([C:15]3[CH:20]=[CH:19][C:18]([O:21][CH2:22][C:23]4([CH3:30])[CH2:27][O:26]C(C)(C)[O:24]4)=[CH:17][CH:16]=3)[CH2:11][CH2:10]2)=[CH:6][CH:5]=1.C(O)C.Cl.C(=O)([O-])[O-].[Na+].[Na+]>C(OCC)(=O)C.O>[CH3:30][C:23]([OH:24])([CH2:22][O:21][C:18]1[CH:19]=[CH:20][C:15]([N:12]2[CH2:11][CH2:10][CH:9]([O:8][C:7]3[CH:6]=[CH:5][C:4]([O:3][C:2]([F:34])([F:1])[F:33])=[CH:32][CH:31]=3)[CH2:14][CH2:13]2)=[CH:16][CH:17]=1)[CH2:27][OH:26]

Komponenten

7

Edukt 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 10340Sodium CarbonateHCID 673611244-[4-(Trifluoromethoxy)phenoxy]-1-{4-[(2,2,4-trimethyl-1,3-dioxolan-4-yl)methoxy]phenyl}piperidine

Produkt 1

HCID 53345566HCID 53345566, VerbindungAusbeute 96 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

4-[4-(Trifluoromethoxy)phenoxy]-1-{4-[(2,2,4-trimethyl-1,3-dioxolan-4-yl)methoxy]phenyl}piperidine (223 mg, 0.463 mmol), ethanol (10 mL), and concentrated hydrochloric acid (2 mL) were mixed and stirred at room temperature for 14 hours. Water was added to the reaction mixture, followed by neutralization with sodium carbonate. Ethyl acetate was added to the mixture to conduct extraction. The organic layer was washed with water three times. The organic layer was concentrated under reduced pressure, obtaining 196 mg (yield: 96%) of the objective compound.

Aufarbeitung

  1. extractionextraction
  2. washThe organic layer was washed with water three times
  3. concentrationThe organic layer was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-9b754cd50a224bc8a3e3151308539ff2
Quelldatensatz
uspto-grants-2013_12
Patentnummer
US08598358B2

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