Magnesium peroxide (Mg(O2)) → 4-Methyl-1-phenylisoquinoline

HRID 1910341

Reaktionsgleichung

Reaktionsgleichung von HRID 1910341
[O-][O-].[Mg+2].[C:4]1([C:10]2[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[CH:13]([CH3:20])[CH2:12][N:11]=2)[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1>C1C=CC=CC=1>[C:4]1([C:10]2[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[C:13]([CH3:20])=[CH:12][N:11]=2)[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1

Komponenten

4

Edukt 2

HCID 61745Magnesium peroxide (Mg(O2))HCID 131435804-Methyl-1-phenyl-3,4-dihydroisoquinoline

Produkt 1

HCID 128434954-Methyl-1-phenylisoquinolineAusbeute 42,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 241BenzeneLösungsmittel

Versuchsvorschrift

To a suspension of activated magnesium dioxide (270 g, 0.132 mol) in 550 mL of benzene was added 1-phenyl-4-methyl-3,4-dihydroisoquinoline (29.0 g, 0.131 mol) with stirring. The reaction mixture was heated at reflux for 16 hours. The magnesium dioxide was removed by vacuum filtration and washed with methylene chloride. Evaporation of the solvent yielded 12.2 g (42%) of pure yellow crystals of 1-phenyl-4-methylisoquinoline.

Aufarbeitung

  1. temperatureThe reaction mixture was heated
  2. temperatureat reflux for 16 hours
  3. customThe magnesium dioxide was removed by vacuum filtration
  4. washwashed with methylene chloride
  5. customEvaporation of the solvent

Quellen und Nachweise

ORD-Eintrag
ord-713ee148d584444f812fc7d9b29f8c64
Quelldatensatz
uspto-grants-2013_12
Patentnummer
US08603645B2

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